Identification of a quantitative trait locus (QTL) associated with striatal <i>HTT</i> CAG instability.

Linkage analysis in 10-week-old (B6x129).HdhQ111/+ F2 mice (n = 69) identified a single QTL on chromosome 9, with a maximum LOD score of approximately 14 and a 2-LOD-dropoff interval of 5 Mb (chr9:107,982,655–113,057,967; GRCm38/mm10) (Figure S6). Note that the 2 markers positioned within the Mlh1 gene (dbSNP rs30131926 and rs30174694) define the QTL peak. The red dashed line represents the threshold (LOD = 4.3) considered for the identification of significant QTLs [85]. The coordinates (cM) of the 147 genetic markers used are represented by open triangles.