Transcriptome of nonpregnant myometrial specimens with or without the medroxyprogesterone treament

Timely control of parturition is crucial for maternal and fetal health. Failures on this biological process often result in pregnancy complications including preterm birth, labor dystocia, and health disorders on newborn babies. The myometrium is the muscular structure of the uterus maintaining uterine structural integrity and providing contractile force for parturition. The myometrial structure changes in adaptation to the pregnancy via stage-specific transcriptomic profiles. Progesterone signaling plays a crucial role in myometrial remodeling. The present study profiles the transcriptome of human myometrial specimens that are expected to manifest a wide spectrum of progesterone signaling via the RNAseq assay. Overall design: Nonpregnant myometrial specimens were subject to the RNAseq assay to document gene expression profiles in proliferative, mid-secretary, post-menopausal, and provera (medroxyprogesterone)-treated groups.