Overall rare^* variant mutation burden: all genes.

*rare variants were defined as follows: seen only in either cases or controls exclusively, missense, nonsense, splice site, or start or stop codon disruptions with a frequency of less than 2% in this data, and less than 1% in all populations in the Exome Variant Server[38] and SeattleSNP[39] databases Overall rare* variant mutation burden: all genes.