Mutual Folding Induced by Binding Database

Mutual Folding Induced by Binding (MFIB) is a repository of protein complexes for which the folding of each constituent protein chain is coupled to the interaction forming the complex. This means that while the complexes are stable enough to have their structures solved by conventional structure determination methods (such as X-ray or NMR), the proteins or protein regions involved in the interaction do not have a stable structure in their free monomeric form (i.e. they are intrinsically disordered/unstructured).

结合诱导协同折叠（Mutual Folding Induced by Binding, MFIB）是一个蛋白质复合物数据集，其中每条组成蛋白链的折叠过程与复合物形成过程中的相互作用紧密耦合。具体而言，尽管此类复合物结构足够稳定，可通过常规结构解析方法（如X射线衍射法或核磁共振（NMR））解析其三维结构，但参与相互作用的蛋白质或蛋白质区域在游离单体状态下并不具备稳定结构，即属于内在无序/非结构化蛋白。

搜集汇总

背景与挑战

背景概述

MFIB 2.0是一个专门存储由内在无序或不稳定蛋白质链形成的蛋白质复合物的数据库，这些蛋白质在单体状态下缺乏稳定结构，其折叠过程依赖于复合物组装时的协同作用。该数据库提供了经过精选和注释的此类复合物集合，旨在补充内在无序蛋白质相互作用的研究领域。