Somatic hypermutation (SHM), initiated by activation-induced cytidine deaminase(AlD), generates a pool of mutations in antibody-coding sequence to allow affinitymaturation upon pathogen invasion. Why
Somatic hypermutation (SHM) and class switch recombination (CSR) diversify immunoglobulin (Ig) genes and are initiated by the activation induced deaminase (AID), a single-stranded DNA cytidine deamina
Antibody diversification necessitates targeted mutation of regions within the immunoglobulin locus by activation-induced cytidine deaminase (AID). While AID is known to act on single-stranded DNA (ssD
