Mouse ear tissue at 21 days post immunization. Mouse ear tissue at 21 days post immunization

Gene expression analysis using nCounter immunology panel for profiling among naïve controls and immunized treatment samples. We explored the interplay between type-I IFNs and the development of host protective Th1 immunity in mice immunized with LmCen-/- parasites and challenged with L. donovani parasites and show that downregulation of IRF7 mediated production of IFN-α/β is critical for the induction of protective immunity. Overall design: In this study, using transcriptomics, we present differential gene exression to evaluate early immune response conditions upon immunization.