Comparison of disease activity over 2 years in placebo SPMS versus placebo PPMS by various definitions of intermittent activity, progression, and improvement.

aFor each clinical disease activity pattern (intermittent, clinical progression 1, clinical progression 2, and improvement) we present the median percentage as an average of all the measurements within each category.bAll P values have been adjusted for multiple comparisons.cBrain parenchymal fraction (BFP) was measured in IMPACT study while whole brain volume was measured in OLYMPUS study. For the purpose of multiple comparison correction, MRI progression was considered as a single variable (with MRI progression 1, 2, and 3 being presented as a sensitivity analysis).