MGH AF Study: Exome Sequencing in Early-Onset Atrial Fibrillation

This substudy phs001117 Massachusetts General Hospital (MGH) AF Study: Exome Sequencing Study includes exome sequencing for subjects with early-onset atrial fibrillation. Summary level phenotypes for the Massachusetts General Hospital (MGH) Atrial Fibrillation (AF) Study participants can be viewed at the top-level study page [phs001001](./study.cgi?study_id=phs001001) MGH AF Study. Individual level phenotype data and molecular data for all MGH AF top-level study and substudies are available by requesting Authorized Access to the MGH AF Study [phs001001](./study.cgi?study_id=phs001001).

The Massachusetts General Hospital (MGH) Atrial Fibrillation Study was initiated in 2001. The study has enrolled serial probands, unaffected and affected family members with atrial fibrillation. At enrollment participants undergo a structured interview to systematically capture their past medical history, AF treatments, and family history. An electrocardiogram is performed; the results of an echocardiogram are obtained; and blood samples are obtained.