HTZ-1 is enriched at genes essential for growth and development.

HTZ-1 peaks that could be unambiguously annotated to a single gene (either unidirectional promoters or coding regions) were selected. GoTermFinder [43] was used to find Gene Ontology (GO) Terms that are overrepresented among HTZ-1 associated loci. The number of HTZ-1 bound loci annotated to each GO term is shown in column 3, with the fraction of all HTZ-1 loci shown in parenthesis. For comparison, column 4 displays the total number of genes annotated to each GO term, with the fraction of all genes shown in parenthesis. The significance (corrected p-value) of overrepresentation is shown in column 5. All overrepresented GO terms with a corrected p-value less than 1×10−20 and farthest down the ontology tree are shown; for an expanded list see Table S2.