Crebbp loss drives small cell lung cancer and increases sensitivity to HDAC inhibition [pituitary tumor]

This study assessed tumor suppressor roles of CREBBP in SCLC and other neuroendocrine tumors. Genetically engineered mouse models were used to determine the tumor suppressor role of Crebbp in SCLC and other neuroendocrine tumors. Identification of differentially expressed genes regulated by Crebbp using primary pituitary tumors derived from genetically engineered mouse model.