Average classification MCC score assessed by LOPO-CV to separate voxels with the grade III versus grade IV in the brain tumor dataset.

MBPLS-DA is used instead of PLS-DA for the last line given the multiple types (i.e. MR spectra and MR images). Average MRI data are obtained from MR images by averaging pixels intensities for all voxels. Metabolites peaks, corresponding to brain metabolites, are quantified from MR spectra. Full MR spectra means that complete MR spectra are used as input data. Standard deviation is reported below each score between brackets. The best results are underlined.