Mitochondria-related gene sets are not enriched for associations with type 2 diabetes-related glycemic traits.

is the nominal gene set enrichment p-value for gene set gs computed for each glycemic trait separately. The enrichment cutoff calculated for each phenotype is the 95th percentile of all gene p-values computed from the corresponding GWA study meta-analysis. HOMA-IR is an index for insulin resistance, HOMA-B is an index for ß-cell function, and HbA1c represents glycated hemoglobin concentrations, which is a measure of long-term plasma glucose concentrations.
‡Not significant after Bonferroni correction (most stringent cutoff p<0.002 given 3 gene sets and 8 traits; a less stringent cutoff, p<0.0083 correcting for 3 gene sets and 2 traits due to correlation between the glucose and insulin-related traits).