Dataset for 3,3'-Dichlorobiphenyl (PCB 11) Alters the Hepatic Expression of Cytochrome P450 Enzymes in the Liver of Mouse Dams Exposed Orally During Pregnancy and Lactation.

As part of a larger study on neurodevelopmental effects of lower‑chlorinated PCB 11, we characterized PCB 11 distribution in postweaning mouse dams orally exposed to PCB 11 via the diet. We used liquid chromatography mass spectrometry-tandem mass spectrometry (LC‑MS/MS) to map global changes in hepatic protein levels, gas chromatography mass spectrometry-tandem mass spectrometry (GC‑MS/MS) to quantify PCB 11 and its metabolites in brain, liver, and serum; and liquid chromatography-high resolution mass spectrometry (LC-HRMS) to screen serum for additional PCB 11 metabolites. The accompanying dataset contains raw and processed files from the GC-MS/MS and LC-HRMS, including PCB 11 and associated metabolite concentrations, detection limits, recoveries, and chromatogram peak areas. The LC-MS/MS proteomics dataset is publicly available through the University of California, San Diego’s Center for Computational Mass Spectrometry MassIVE Repository (MSV000099827) and ProteomeXchange Consortium (PXD070556) under the DOI: https://doi.org/10.25345/C56W96P25.