Proteogenomics Dashboard for the Human Proteome Project

dasHPPboard is a novel proteomics-based dashboard
that collects and reports the experiments produced by the Spanish
Human Proteome Project consortium (SpHPP) and aims to help HPP to
map the entire human proteome. We have followed the strategy of analog
genomics projects like the Encyclopedia of DNA Elements (ENCODE),
which provides a vast amount of data on human cell lines experiments.
The dashboard includes results of shotgun and selected reaction monitoring
proteomics experiments, post-translational modifications information,
as well as proteogenomics studies. We have also processed the transcriptomics
data from the ENCODE and Human Body Map (HBM) projects for the identification
of specific gene expression patterns in different cell lines and tissues,
taking special interest in those genes having little proteomic evidence
available (missing proteins). Peptide databases have been built using
single nucleotide variants and novel junctions derived from RNA-Seq
data that can be used in search engines for sample-specific protein
identifications on the same cell lines or tissues. The dasHPPboard has been designed as a tool that can be used to share and visualize
a combination of proteomic and transcriptomic data, providing at the
same time easy access to resources for proteogenomics analyses. The dasHPPboard can be freely accessed at: http://sphppdashboard.cnb.csic.es.