Additional file 1 of The lung microbiome, peripheral gene expression, and recurrence-free survival after resection of stage II non-small cell lung cancer

Additional file 1: Supplementary Table 1. Predictors of RFS, DFS, and OS in Cox proportional hazards models. Adjusted models are adjusted for all other covariates shown here. Supplementary Table 2. Association of richness and the Shannon diversity index with RFS, DFS, and OS in Cox proportional hazards models. Analyses were performed on the tumor tissue microbiome data and normal tissue microbiome data. Adjusted models are adjusted for age, sex, race, histology, smoking, and chemotherapy. Supplementary Table 3. Association of taxa with RFS, DFS, and OS in Cox proportional hazards models. Analyses were performed on the tumor tissue microbiome data and normal tissue microbiome data. All models are adjusted for age, sex, race, histology, smoking, and chemotherapy. We also performed 500 × 10-fold cross-validated elastic-net penalized Cox regression, and show the number of times each taxa was selected out of 500. Penalized regression and FDR-correction were performed on each taxonomic level separately. Supplementary Table 4. Association of functional pathways with RFS, DFS, and OS in Cox proportional hazards models. Analyses were performed on the tumor tissue microbiome data and normal tissue microbiome data. All models are adjusted for age, sex, race, histology, smoking, and chemotherapy. We also performed 500 × 10-fold cross-validated elastic-net penalized Cox regression, and show the number of times each function was selected out of 500. Supplementary Table 5. Information on MetaCyc pathways related to RFS, DFS, or OS. Supplementary Table 6. Association of gene expression in buffy coat with RFS, DFS, and OS in Cox proportional hazards models. All models are adjusted for age, sex, race, histology, and smoking. We also performed 500 × 10-fold cross-validated elastic-net penalized Cox regression, and show the number of times each gene was selected out of 500. Genes highlighted in yellow are those correlated (p<0.01) with at least one survival-related taxa/functional pathway in normal lung.