Biodegradable Nanoparticles Induce cGAS/STING-dependent Reprogramming of Myeloid Cells to Promote Tumor Immunotherapy. Biodegradable Nanoparticles Induce cGAS/STING-dependent Reprogramming of Myeloid Cells to Promote Tumor Immunotherapy

Spleens were collected from C57BL/6 mice that were treated with (1) saline, (2) a single dose of nanoparticles, (3) 3 doses of nanoparticles administered daily, or (4) 3 doses of nanoparticles administered every 3 days. Single-cell RNA-sequencing was conducted using the 10X Genomics platform and analyzed with Seurat.