GWAS/GWIS top results.

Most significant results for genome-wide association with vegetarianism (top) and genome-wide interaction with vegetarianism across 30 biomarker traits (bottom), for variant-level and gene-level analyses. All traits analyzed in standard and BMI-adjusted models. Start and stop coordinates of genes represent the +2 Kbp upstream and -1 Kbp downstream window of variant P-value aggregation used in MAGMA. CHR, chromosome; POS, position; Nveg, number of vegetarians in analysis; Nnonveg, number of nonvegetarians in analysis; A0, other allele; A1, effect allele; A1Freq, effect allele frequency; Beta Marginal, coefficient estimate for the marginal genetic effect (i.e., from a model with no interaction terms); Beta Marginal SE, robust standard error for beta marginal; Beta G, coefficient estimate for the genetic main effect; Beta G SE, robust standard error for beta G; Beta interaction, coefficient estimate for the interaction term; Beta interaction SE, robust standard error for beta interaction; P marginal, marginal genetic effect P-value from robust SE; P interaction, interaction P-value from robust SE; P joint, joint test P-value (2 degrees of freedom test of genetic and interaction effect) from robust SE. NSNPS, number of SNPs annotated to the top gene; NPARAM, number of relevant parameters used in model; P interaction (MULTI), gene P-value for best fit of “mean” and “top” models as determined by MAGMA.
(XLSX)