Expression profiling of monkey with endometriosis before and after treatment with anti-IL8 antibody

Hormone drugs can relieve pain in endometriosis patients but cannot cure the disease, so curative therapy for endometriosis is an urgent unmet medical need. We found that the progression of endometriosis is associated with inflammation and fibrosis. In addition, IL-8 expression was highly upregulated in endometriotic tissues and closely correlated with disease progression. To develop a disease-modifying drug for endometriosis, we created a long-acting recycling antibody against IL-8 and evaluated its clinical potency in monkeys with spontaneously developed or surgically induced endometriosis. As part of the evaluation, we performed the fast gene set enrichiment analysis and upstream regulator analysis(Ingenuity pathway analysis) with RNA sequencing data from monkey with spontaneouly developled endometriosis before and after anti-IL8 antibody treatment.