Analysis of MYO9B, PARD3 and MAGI2 SNPs in the Dutch and German cohorts and joint analysis.

OR, odds ratio; 95% CI, 95% confidence interval; RAF, risk allele frequency. # Risk variant/second allele* Two-tailed P-values were calculated by chi-squared test for independence of allele counts$Heterogeneity between the cohorts (Breslow-Day test).The risk variant was the associated allele in the Dutch cohort; the same variant frequencies were reported for the German cohort. A combined analysis of the Dutch and German results was performed using Cochran-Mantel-Haenszel analysis with 50,000 random permutations. This generated two P-values (P-joint and P-adjusted), an OR and 95% CI. P-joint shows an individual SNP’s significance in the combined cohort. P-adjusted was obtained after correcting for multiple testing. SNPs rs2305767 and rs6962966 showed modest evidence for heterogeneity between the Dutch and German cohort when a Breslow-Day test was performed on this data.