Linear and Pre-organized Carboxylic Acid Picket Porphyrins as Bismuth Chelators

New picket porphyrins delivering at least one carboxylic group around the coordination site of the macrocycle were
synthesized for bismuth coordination. The influence of the number, the length, and the pre-organization of the
carboxylic acid pickets on the stability of the bismuth complexes was explored. Their stabilities in acidic medium
were compared with those of their precursors bearing ester pickets. The molecular structure of one of the bismuth
complexes, which is the only monomeric bismuth porphyrin reported up to now, is discussed. At the opposite of
what we initially reported, and in agreement with the theoretical calculations, the distortion of the macrocycle in this
structure is mainly due to the number of water molecules in the first sphere of coordination of the bismuth.