Processes that define immunoglobulin repertoires are commonly presumed to be the same for all murine B cells. However, studies here that couple high-dimensional FACS sorting with large-scale quantitat

NIAID Data Ecosystem20

Abundant heterozygous IGHV genes in individual 2 from Healthy PBMC datasets (Fig 4) and individual 5 from the Intestinal datasets (Figure J).

B细胞受体多样性

IGHV基因

For individual 2, only the IgM datasets were used. For individual 5, only the naive datasets were used.

Figshare2020-04-27 更新10

The Number of Overlapping AID Hotspots in Germline IGHV Genes Is Inversely Correlated with Mutation Frequency in Chronic Lymphocytic Leukemia

淋巴细胞白血病分子机制

IGHV基因

The targeting of mutations by Activation-Induced Deaminase (AID) is a key step in generating antibody diversity at the Immunoglobulin (Ig) loci but is also implicated in B-cell malignancies such as ch

NIAID Data Ecosystem20

Abundant heterozygous IGHV genes in individual 2 from Healthy PBMC datasets (Fig 4) and individual 5 from the Intestinal datasets (Figure J).

免疫基因多样性

IGHV基因

For individual 2, only the IgM datasets were used. For individual 5, only the naive datasets were used.

NIAID Data Ecosystem20