Crystal structure of human NUAK1-MARK3 kinase domain chimera bound with small molecule inhibitor #10
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Crystal structure of human NUAK1-MARK3 kinase domain chimera bound with small molecule inhibitor #10 Descriptor: (6P)-6-[(4S)-imidazo[1,2-a]pyridin-3-yl]-4-[(1R)-1-phenylethyl]-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one, 1,2-ETHANEDIOL, MAP/microtubule affinity-regulating kinase 3, ... Authors: Delker, S.L, Abendroth, J. Deposit date: 2023-10-19 Release date: 2024-10-23 Last modified: 2025-06-04 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Discovery of UCB9386: A Potent, Selective, and Brain-Penetrant Nuak1 Inhibitor Suitable for In Vivo Pharmacological Studies. J.Med.Chem., 67, 2024
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2023-10-19
