Teaching Reform Practice of Supercritical Fluid Extraction Technology in Natural Product Separation Experiment： Taking Green Extraction Process of Artemisinin as an Example

As a cornerstone experimental course in applied chemistry， pharmaceutical engineering， and biological science， the natural product separation is pivotal in developing students' practical skills and engineering competencies. This educational reform initiative introduces supercritical fluid extraction （SCFE） technology into the undergraduate curriculum， using artemisinin extraction as a case study to construct a comprehensive， green chemistry-oriented teaching model. The reform features a holistic instructional design-integrating pre-class online modules， in-class hands-on training， and post-class extended tasks-complemented by a multi-dimensional assessment framework. Implementation results demonstrate significant effectiveness： 76.4% of students achieved a systematic understanding of SCFE principles and their practical applications； 81.3% reported a reinforced grasp of green extraction techniques through direct experimentation； and 68.1% found the open-ended， exploratory tasks markedly enhanced the course's challenge level， effectively stimulating innovative thinking and problem-solving skills. By establishing this integrated teaching paradigm and evaluation system， this study provides a replicable model for greening natural product experiments， with potential to drive the sustainable transformation of laboratory education across related disciplines.