The non-obese diabetic mouse sequence, annotation and variation resource

we have established that the variation rate in the Idd regions is 2.3 times higher than the mean found for the whole genome assembly for the NOD/ShiLtJ genome, which we suggest reflects the fact that positive selection for functional variation in immune genes is beneficial in regard to host defence.本研究已证实，Idd区域的变异率较NOD/ShiLtJ小鼠全基因组组装的平均变异率高出2.3倍。本研究认为，这一结果反映了免疫基因功能变异所承受的正向选择，有助于宿主的免疫防御。

搜集汇总

背景与挑战

背景概述

该数据集提供了非肥胖糖尿病小鼠的序列、注释和变异资源。研究发现，在Idd区域的变异率比该小鼠全基因组组装的均值高出2.3倍，这提示免疫基因的功能变异可能经历了正向选择，从而有利于宿主防御。