Predicted miR135a targets in the Wnt signaling pathway.

A large number of genes involved in canonical Wnt signaling (including ligands, receptors and downstream transcriptional regulators) are bioinformatically predicted targets of miR135a by TargetScan and miRanda. A handful of genes (Drapc1, Ctnnb1, Cav1, Cul3, Cxxc4, Dact1, Frat2, Lmna, Macf1, Pas5a, Porcn, Ppp2ca, Sost, Sostdc1, Wif1 and Wls) were not found to be targets by these algorithms. This result suggests that miR135a2 likely acts through multiple levels of the Wnt cascade to modulate Wnt signaling.