Genome sequence of EUFAM dyslipidemia pedigree members. Homo sapiens

The Finnish EUFAM dyslipidemia pedigrees represent a unique resource for identifying low-frequency genetic variants with a high impact on a wide range of traits related to lipid metabolism and to cardiovascular disease outcomes. Genomic investigations of more than 100 of these pedigrees including metabolomics profiling, SNP genotyping, RNA sequencing (of blood and adipose tissue), and whole genome sequencing (WGS) of 300 pedigree founders have been completed. This project will extend WGS to an additional 300 individuals from the same pedigrees, selected to provide maximal information for imputation of genetic variation