PC1/3 deficiency impacts POMC processing in human embryonic stem cell-derived hypothalamic neurons
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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http://data.iscr.ac.cn/Article?id=132953d65f5c0126c097565911bfcfce
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资源简介：
We developed a technique for generating hypothalamic neurons from human pluripotent stem cells. Here, as proof-of-principle, we examine the use of these cells in modeling of a monogenic form of severe obesity: PCSK1 deficiency. We generated PCSK1 (PC1/3)-deficient human embryonic stem cell (hESC) lines using both shRNA and CRISPR-Cas9, and investigated pro-opiomelanocortin (POMC) processing using hESC-differentiated hypothalamic neurons.
提供机构：
Regeneron Pharmaceuticals, Inc.
创建时间：
2022-02-20
