官方服务：
资源简介：
Germ cell methylation dynamics
应用场景：
创建时间：
2015-03-24
相关数据集
Sequential enhancer state remodelling defines human germline competence and specification [ULI-NChIP-seq]. Sequential enhancer state remodelling defines human germline competence and specification [ULI-NChIP-seq]
Germline-soma segregation is a fundamental event during mammalian embryonic development. Here we establish the epigenetic principles of human primordial germ cell (hPGC) development using in vivo hPGC
NIAID Data Ecosystem60
Depletion of tet2 results in age-dependent changes in DNA methylation and gene expression in a zebrafish model of myelodysplastic syndrome [DNAmethylation]
Myelodysplastic Syndrome (MDS) is a heterogenous group of clonal hematopoietic disorders characterized by ineffective hematopoiesis, cytopenias and dysplasia. The gene encoding Ten-ele¬ven translocati
NIAID Data Ecosystem30
Longitudinal change in blood DNA epigenetic signature after smoking cessation
Cigarette smoking is associated with epigenetic changes that may be reversible following smoking cessation. Whole blood DNA methylation was evaluated in Framingham Heart Study Offspring (n = 169) and
NIAID Data Ecosystem20
Prenatal overexposure to the synthetic glucocorticoid dexamethasone (Dex) in rats reduces birthweight in the first generation (F1) and second generation (F2), including through the male line. We hypothesised that the mechanism for this would likely be epigentic perturbations in the male germline. DNA methylation profiling of F1 male germ cells at E19.5 and small RNA expression and Chromatin Immunoprecipitation (ChIP) sequencing for H3K4me1, H3K4me3, H3K27me3 and H3K9me3 on F1 sperm were used to test this hypothesis. No differences in DNA methylation, histone modifications or small RNA expression were observed, suggesting non-epigentic mechanisms may be responsible for the transmission of programmed effects in this model.
Background. Early life exposure to adverse environments affects cardiovascular and metabolic systems in the offspring. These âprogrammed effectsâ are transmissible to a second generation through b
NIAID Data Ecosystem60
Transcription Across the H19/Igf2 Imprinting Control Region Initiates Paternally Methylated Imprinting in Mouse Prospermatogonia (ChIP-Seq)
The insulator model explains the workings of the H19 and Igf2 domain in the soma, where insulation of the Igf2 promoter from its enhancers occurs by CTCF in the maternally inherited unmethylated chrom
NIAID Data Ecosystem20
