A Synthetic Route to Chiral 1,4-Disubstituted Tetrahydro-β-Carbolines via Domino Ring-Opening Cyclization of Activated Aziridines with 2‑Vinylindoles
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https://figshare.com/articles/dataset/A_Synthetic_Route_to_Chiral_1_4-Disubstituted_Tetrahydro-_-Carbolines_via_Domino_Ring-Opening_Cyclization_of_Activated_Aziridines_with_2_Vinylindoles/4683313
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资源简介：
A simple and efficient
strategy for the synthesis of various 1,4-disubstituted
tetrahydro-β-carbolines with excellent stereoselectivity (de,
ee up to >99%) via domino ring opening cyclization (DROC) of activated
aziridines with 2-vinylindoles is described. The reaction proceeds
through LiClO4-catalyzed Friedel–Crafts-type alkylation
of 2-vinylindoles with activated aziridines followed by an intramolecular
aza-Michael reaction in a domino fashion.
创建时间：
2017-02-22
