Additional file 1 of Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk

Additional file 1: Table S1. Genome-wide significant independent SNPs for Body Mass Index in women (Pulit 2018). Table S2. Genome-wide significant independent SNPs for Years Ovulating (Hg19). Table S3. Genome-wide significant independent SNPs for age at menarche downloaded from the ReproGen Consortium Website (Perry et al., 2014; Hg19). Table S4. Genome-wide significant independent SNPs for age at menopause downloaded from the ReproGen Consortium Website (Hg19; Day et al., 2015). Table S5. Genome-wide significant independent SNPs for number of live births extracted from Warrington et al., 2021 (Hg19). TableS6. Genome-wide significant independent SNPs for age at last live birth (Hg19). Table S7. Genome-wide significant independent SNPs for Endometrial Cancer used in the bidirectional MR analyses (Hg19). Table S8. Overview of SNPs and possible pleiotropic effects (Hg19). The direction of the association with other traits in PhenoScanner (i.e. positive (+) or negative(-)) is indicated. Table S9. Basic characteristics of the study participants in UK Biobank. Table S10. Results from the multivariate observational analyses of reproductive risk factors and endometrial cancer risk. Table S11. Results from the multivariate observational analyses of number of live births and other reproductive risk factors on endometrial cancer risk. Table S12. Heterogeneity and Directional Pleiotropy tests from MR analysis of female fertility and risk of endometrial cancer. Table S13. Univariate Mendelian randomization results with only the SNPs included in the primary multivariable MR. Table S14. Results from two Multivariable Mendelian Randomization analyses including the exposures A) BMI, age at menarche, age at menopause and number of live births; and B) BMI, age at menarche, years ovulating and number of live births. Table S15. Overview of all SNPs (Hg19) and their association with the different traits included in the multivariable MR analysis. Table S16. Results from the Multivariable Mendelian Randomization analysis including the exposures age at menarche, age at menopause, years ovulating, number of live births and age at last live birth. Table S17. MR analysis of liability to endometrial cancer on number of live births.