Cobalt-Catalyzed Peroxidation of 2‑Oxindoles with Hydroperoxides

A highly efficient
and facile cobalt-catalyzed C–H activation
and peroxidation of 2-oxindoles was reported, which provides a new
pathway for the synthesis of biologically active 3-peroxy-2-oxindoles
from readily available starting materials in excellent chemical yields.
The resulting products could be further transformed into various substituted
3-peroxyoxindoles in good to excellent yields. The developed method
has been successfully applied to the synthesis of the natural product
(±)-N-[2-(3-hydroxy-2-oxo-2,3-dihydro-1H-indol-3-yl)­ethyl]­acetamide.