Source Data for Supporting Information

Immunohistochemistry (IHC) was visualized
by using an automatic multispectral imaging system with associated software
(Vectra II, PerkinElmer, version 2.0.7.1). The size and zeta potential of HLPC
and M@HLPC were measured by using a nanoparticle tracking analysis (NTA,
Particle Metrix, Germany, version 8.05.04). The absorbance was measured by
automatic microplate reader with associated software (Tecan Infinite M200,
version 1.6.19.2). The interaction between each sub-component in HLPC were
measured by microscale thermophoresis (MST, NT.115, Nanotemper, Germany). Flow
cytometry data was acquired with Backman CytoFLEX LX Flow Cytometer with
associated software (version 2.3.1.22). The biodistribution of nanoparticles
were observed by using IVIS imaging system (PerkinElmer, USA, version 4.5.5).

Power analysis of the animal experiments
indicated that the chosen sample sizes per group are sufficient. We also
referred to relevant literature to determine sample sizes. For the in vitro and
in vivo experiments, we followed standards of good scientific practice. We used
at least 3 biological replicates or 3 animals per group, to calculate means and
standard deviations and to perform statistical analyses.

Statistical analyses were performed using
GraphPad Prism 8.0. Data were analyzed by two-tailed unpaired Student’s t-tests
(two groups) or One-way ANOVA (multiple-groups). P values less than 0.05 were
considered statistically significant.