Effect of nutritional treatments on the oral microbiome in Crohn's disease

Changes to the oral microbiome have been described in patietns with Crohn;s disease. Here we examine the impacts of nutritional therapies in the oral microbiome in pediatric Crohn's disease (CD) patients. CD patients exhibited increased abundance of Actinomyces species and reduced Porphyromonas, Neisseria, Haemophilus and Alloprevotella species. Disease remission was associated with restoration of these taxa. A modified dysbiosis index was developed that could discriminate active disease from remission and could indicate the effectiveness of treatment in real-time.