IMPC

**Abstract(s):** The International Mouse Phenotypic Consortium [(IMPC)](https://www.mousephenotype.org) is an international effort by 21 research institutions to identify the function of every protein-coding gene in the mouse genome. To achieve this, the IMPC is systematically switching off or ‘knocking out’ each of the roughly 20,000 genes that make up the mouse genome. Subsequently, the knock out mice undergo standardised physiological tests (phenotyping tests) across a range of biological systems in order to infer gene function. The overall aim of the project is not only to develop insight into the function of every gene, but also to provide transformative insights into the genetic basis of disease that will impact upon clinical diagnosis and management and ultimately prevent, detect, diagnose and treat disease. This published dataset is based on hundreds of E15.5 and E18.5 mouse models, all of which are homozygous knockouts, excluding the wildtype littermates.

**摘要**：国际小鼠表型组联盟（International Mouse Phenotypic Consortium, IMPC，网址：https://www.mousephenotype.org）是由21家研究机构联合开展的国际合作项目，旨在解析小鼠基因组中每一个蛋白编码基因的功能。为实现这一目标，IMPC正系统性地对小鼠基因组中约20000个编码基因逐一进行敲除（knockout）操作。后续，研究人员将对这些基因敲除小鼠开展覆盖多类生物系统的标准化生理测试（表型测试），以此推断对应基因的功能。该项目的整体目标不仅在于阐明每一个基因的功能，更在于为疾病的遗传基础提供突破性见解，进而助力临床诊断与治疗管理，并最终实现疾病的预防、早期筛查、确诊及干预。本次发布的数据集基于数百例E15.5与E18.5阶段的小鼠模型，所有模型均为纯合基因敲除（homozygous knockout）小鼠，未纳入野生型（wildtype）同窝对照个体。