Binding Profiles of Myc and RNA Polymerase II in Rat Neonatal Cardiomyocytes
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https://www.ncbi.nlm.nih.gov/sra/SRP071202
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资源简介：
During the progression of cardiac hypertrophy, cardiomyocytes accelerate RNA biogenesis to meet increasing metabolic demands under exogenous hypertrophic stimuli. We have elucidated the quantitative kinetics of RNA in c-Myc (Myc)-mediated hypermetabolic analytical model using cultured neonatal rat cardiomyocytes. Chromatin immunoprecipitation and high-throughput sequencing demonstrate that overexpressed Myc binds to a specific set of genes directly in cardiomyocytes and recruits RNA polymerase II to these genes. Overall design: ChIP-sequence using rat neonatal cardiomyocytes transduced by adenovirus encoding Myc or LacZ control in duplicates.
创建时间：
2017-09-17
