EGFR kinase (T790M/V948R) in complex with osimertinib and JBJ-09-063
收藏Protein Data Bank Japan2024-11-13 更新2026-03-21 收录
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EGFR kinase (T790M/V948R) in complex with osimertinib and JBJ-09-063 Descriptor: (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{6-[4-(1-methylpiperidin-4-yl)phenyl]-1-oxo-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide Authors: Beyett, T.S, Eck, M.J. Deposit date: 2020-08-28 Release date: 2021-09-08 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Molecular basis for cooperative binding and synergy of ATP-site and allosteric EGFR inhibitors Nat Commun, 13, 2022
创建时间：
2020-08-28
