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Gremlin 1 + fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues

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NIAID Data Ecosystem2026-03-13 收录
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Although cross-species transcriptional analysis has been generated for DCs37, transcriptomic conservation between mouse and human FRCs at single-cell resolution has been unclear. To test whether GREM1+ FRCs might also play a role in DC homeostasis in humans, we performed scRNA-seq of CD45–PDPN+ stromal cells, as well as CD45+CD11c+ immune cells from healthy human LNs of three donors.EGA study EGAS00001006211

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2022-04-21
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