Pulmonary tuberculosis (PTB) symptomatic individuals, their sociodemographic characteristics, genetic diversity and drug resistance patterns of Mycobacterium tuberculosis strains

This dataset described the entire number of adult holy water sites (HWS) attendees (≥18 years of age) who were screened for Pulmonary Tuberculosis (PTB) -suggestive symptoms at nine selected study zones (HWS) found across the study region. During the study period, a total of 10,313 adult HWS (≥ 18 years of age) were screened, and 560 individuals were PTB symptomatic and participated. Out of 560 PTB symptomatic HWS attendees who participated, 122 (21.8%) were Lowenstein- Jensen (LJ) culture-positive (bacteriologically confirmed cases). Their sociodemographic characteristics and PTB infection risk factors are detailed. All LJ culture-positive isolates were subjected to spoligotyping, resulting in 116 isolates with interpretable spoligo-patterns. We performed drug susceptibility testing for all 122 (LJ culture)-positive isolates using MTBDRplus v2 and MTBDRsl v2 line probe assays.  
Drug-susceptibility testing (DST) results for first and second line anti-TB drugs are detailed in this dataset. Furthermore, a prospective follow-up study on 438 PTB-symptomatic individuals with culture-negative test results was done to determine the prevalence of developing active TB disease subsequent to residing at a HWS. The duration of follow-up was 12 months, starting on the date that a negative culture result was obtained. Thus, 30 (6.8%) were infected with TB and developed active TB disease post-exposure to HWS. In general, in these attached datasets, details of the study participants, LJ culture-testing results, DST results, as well as genotyping findings of the isolates are illustrated.

本数据集详细描述了研究区域内九个选定区域（圣水场所，HWS）中接受肺结核（PTB）疑似症状筛查的成年圣水场所参与者（≥18岁）的总体数量。在研究期间，共计10,313名成年圣水场所参与者（≥18岁）接受了筛查，其中560人表现出PTB症状并参与了研究。在参与研究的560名PTB症状性圣水场所参与者中，有122人（21.8%）经Lowenstein-Jensen（LJ）培养法检测呈阳性（细菌学确认病例）。他们的社会经济特征和PTB感染风险因素被详细记录。所有LJ培养法检测阳性的分离株均进行了spoligotyping分析，产生了116个具有可解释的spoligo图案的分离株。我们使用MTBDRplus v2和MTBDRsl v2线探针试剂对所有122个（LJ培养法）阳性的分离株进行了药物敏感性测试。该数据集中详细记录了第一线和第二线抗结核药物的药物敏感性测试（DST）结果。此外，针对438名PTB症状性个体进行了前瞻性随访研究，以确定他们在圣水场所居住后发展成活动性TB疾病的患病率。随访期为12个月，从获得阴性培养结果之日开始计算。因此，有30人（6.8%）在接触圣水场所后感染了TB并发展成活动性TB疾病。总的来说，这些附加数据集中详细展示了研究参与者、LJ培养测试结果、DST结果以及分离株的基因分型结果。