PD_NGSAtlas

PD_NGSAtlas aims at providing a reference resource combining both next-generation sequencing epigenomic and transcriptomic data and quantitative analysis of epigenetic and transcriptional alternations involved in psychiatric disorders. The current release of PD_NGSAtlas contains 43 methylation profiles and 37 expression profiles detected by MeDIP-seq and RNA-Seq respectively, in peripheral blood and two distinct brain regions of SZ, BP and non-psychiatric control individuals. In addition to these data generated in-house, we have and will continue to include published DNA methylation and gene expression data from other research groups with the focus on psychiatric disorders. The website offers open and easy access to obtain expression and methylation levels of interesting genes and tools to facilitate the comprehensive annotation and discovery of dysfunctional genes or functional regions. A genome browser is developed to provide integrative and detailed views of multidimensional data under a given genomic context, which can help researchers to better understand pathophysiological mechanism from epigenetic and transcriptional views.