Regio- and Enantioselective Baeyer–Villiger Oxidation: Kinetic Resolution of Racemic 2‑Substituted Cyclopentanones

A kinetic resolution of racemic 2-substituted
cyclopentanones via
highly regio- and enantioselective Baeyer–Villiger oxidation
has been successfully developed. The reaction could afford the normal
6-substituted δ-lactones in up to 98% ee and >19/1 regioselectivity.
Meanwhile, the unreacted ketones were recovered in excellent ee values
(up to 98%). It represents the best results of the kinetic resolution
of racemic 2-substituted cyclopentanones via nonenzymic asymmetric
BV oxidation.