1,2,4-Triazolyl 5‑Azaspiro[2.4]heptanes: Lead Identification and Early Lead Optimization of a New Series of Potent and Selective Dopamine D3 Receptor Antagonists
收藏NIAID Data Ecosystem2026-03-09 收录
下载链接：
https://figshare.com/articles/dataset/1_2_4-Triazolyl_5_Azaspiro_2_4_heptanes_Lead_Identification_and_Early_Lead_Optimization_of_a_New_Series_of_Potent_and_Selective_Dopamine_D3_Receptor_Antagonists/3814737
下载链接
链接失效反馈官方服务：
资源简介：
A novel
series of 1,2,4-triazolyl 5-azaspiro[2.4]heptanes with high affinity
and selectivity at the dopamine (DA) D3 receptor (D3R) is described.
Some of these compounds also have high selectivity over the hERG channel
and were characterized with respect to their pharmacokinetic properties
both in vitro and in vivo during lead identification and early lead
optimization phases. A few derivatives with overall favorable developability
characteristics were selected for further late lead optimization studies.
创建时间：
2016-09-16
