Plasmodium falciparum 20S proteasome bound to inhibitor 296

NIAID Data Ecosystem2026-05-10 收录

疟疾药物研发

蛋白酶体抑制剂

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Plasmodium falciparum 20S proteasome bound to inhibitor 296

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2025-11-26

Aza-peptide aldehydes and ketones: synthesis and evaluation as human 20S proteasome inhibitors

药物开发

蛋白酶体抑制剂

Aza-peptide aldehydes and ketones were developed as a new class of peptidyl analogues to inhibit the human constitutive (c)20S proteasome as alternative therapeutics to treat multiple myeloma (MM). El

DataCite Commons2025-10-18 更新60

Structure-Based Design of β5c Selective Inhibitors of Human Constitutive Proteasomes

蛋白酶体抑制剂

结构导向药物发现

This work reports the development of highly potent and selective inhibitors of the β5c catalytic activity of human constitutive proteasomes. The work describes the design principles, large hydrophobic

Figshare2016-08-11 更新30

Yeast 20S proteasome mutant: beta5_T3M in complex with ONX0914

蛋白酶体抑制剂

结构生物学

Yeast 20S proteasome mutant: beta5_T3M in complex with ONX0914

NIAID Data Ecosystem20

Crystal structure of Plasmodium falciparum GRP78 in complex with Toyocamycin

疟疾药物研发

蛋白质结构解析

Crystal structure of Plasmodium falciparum GRP78 in complex with Toyocamycin

NIAID Data Ecosystem30

Yeast 20S proteasome beta5-L(-49S)_D17N double mutant in complex with Carfilzomib

蛋白酶体抑制剂

药物靶点解析

Yeast 20S proteasome beta5-L(-49S)_D17N double mutant in complex with Carfilzomib Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, MAGNESIUM ION, ... Authors: Huber, E.M, Groll, M. Depo

Protein Data Bank Japan2024-11-13 更新30

Plasmodium falciparum 20S proteasome bound to inhibitor 296

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