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Transcriptome analysis of the CBX3-depleted 143B osteosarcoma cell line.

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NIAID Data Ecosystem2026-03-14 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE224201
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To investigate the role of CBX3 in the progression of osteosarcoma, we performed a transcriptome analysis of the CBX3-depleted 143B cell line and a matched normal 143B cell line.Differential gene enrichment revealed activation of the anti-DNA damage pathway and activation of the apoptotic and P53 pathways. The mRNA profiles of 143B osteosarcoma cells without targeting gene small interfering RNA and targeting CBX3 small molecule interfering RNA were generated by deep sequencing using a Novaseq 6000 sequencer (Illumina).
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2023-03-01
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