Transcranial focused ultrasound neuromodulation on a nonhuman primate model|神经科学数据集|超声技术数据集

In these datasets, we applied low-intensity tFUS stimulation with a customized 128-element random array ultrasound transducer (f0: 700 kHz) in a rhesus macaque monkey engaged in a simple visually-guided saccade task. The stimulation was guided stereotaxically to the frontal eye field (FEF), a region of frontal cortex that guides eye movements. We recorded simultaneously from a 96-channel Utah array implanted in V4, a region of extrastriate visual cortex that receives feedback connections from FEF.The monkey subject was trained to perform tasks while seated in front of a computer screen. A visual stimulus (a natural image) was delivered for 400 ms while the subject maintained fixation. A reward was provided if the subject maintain fixation for the full trial and then followed the fixation dot when it moved to a peripheral location. For most recording sessions, 120 trials only with visual stimulation (400 ms) and 120 trials with concurrent visual and tFUS (300 ms) stimulation were mixed and randomly presented. By applying multiple different ultrasound parameters, those generated local field potentials (LFPs) at V4 were studied and compared. The tFUS was also directed to insula, which does not have substantial connections to V4, to validate the neuromodulation effects at V4 were not due to auditory side effects through skull conductions.The shared datasets include 39 files originated from 13 experimental conditions. The events of visual stimuli and ultrasound stimuli are included in these files. Please see the README file for further information on how to load LFP and spiking data from each dataset. The name of each dataset is corresponding to the figure number as listed in the corresponding manuscript:Yu K, Schmitt S, Ni Y, Crane E, Smith M, He B. Transcranial Focused Ultrasound Remotely Modulates Extrastriate Visual Cortex with Subregion Specificity. bioRxiv: https://doi.org/10.1101/2024.01.20.576476.This work was supported in part by NIH EB029354, NS124564, and NS131069. Animal care and handling are according to the regulation of Institutional Animal Care and Use Committee of Carnegie Mellon University and complied with National Institutes of Health guidelines.If anyone uses the whole or part of the dataset provided here, we kindly ask you to cite the above publication in any of your publications or presentations.