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Harnessing TP73-Targeted Nintedanib: A Novel Strategy to Halt Triple-Negative Breast Cancer via p53-PPARalpha/PI3K-Akt Pathway Suppression

NIAID Data Ecosystem2026-05-02 收录

药物作用机制

三阴性乳腺癌

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP593972 数据链接链接失效反馈

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We employed mRNA sequencing analyses to investigate the molecular mechanisms underlying nintedanib's anti-TNBC proliferative and migratory effects.

应用场景：

创建时间：

2025-06-27

药物作用机制

计算机模拟

This is an Excel file, it is used to analyze the data from the simulations. It has two sheets ’cry’ and ’nocry’ used to generate the Figs. 17 and 18 respectively. (XLSX 41 kb)

Figshare2018-08-30 更新80

Effect of PFTα on the cell cycle phases of HCT116 cells treated with TMZ and NSC666715 either alone or in combination.

细胞周期调控

药物作用机制

Cells were treated with different concentrations of drugs as indicated for 48 h. Cell cycle status and apoptosis were examined by FACS analysis. The percent distribution of cells in the G0/G1, S, G2/M

Figshare2015-12-03 更新30

Details of statistical analyses applied related to Figs 5 and S11.

药物作用机制

细胞周期调控

S8A Table. Western blot analysis after Rapamycin and AZD-8055 treatments—pRPS6/Actin levels. S8B Table. Student t test pairwise comparisons between relative pRPS6/Actin levels from Rapamycin-treated s

Figshare2025-12-08 更新10

Genomic Regulation of Invasion by STAT3 in Triple Negative Breast Cancer

三阴性乳腺癌

STAT3转录调控

Breast cancer is a heterogeneous disease comprised of four molecular subtypes defined by whether the tumor-originating cells are luminal or basal epithelial cells. Breast cancers arising from the lumi

NIAID Data Ecosystem70

Synergy of chemotherapy and macrophage depletion leads to T cell memory activation and durable triple negative breast cancer regression

癌症免疫治疗

三阴性乳腺癌

Chemotherapy and macrophage depletion leads to T cell memory activation and durable triple negative breast cancer regression in p53 null mouse models. Overall design: RNA-seq was performed on 15 'p53

NIAID Data Ecosystem20

Harnessing TP73-Targeted Nintedanib: A Novel Strategy to Halt Triple-Negative Breast Cancer via p53-PPARalpha/PI3K-Akt Pathway Suppression

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