Dimerization of Phospho IRF3 or phospho IRF7

Phosphorylation of these transcription factors IRF3 and IRF7 results in a conformational change that allows their dimerization to form homo- or hetero dimers. Each of the three different combinations of dimers (IRF3:IRF3, IRF7:IRF7 and IRF3:IRF7) may selectively effect the transcription of IFN-alpha gene subfamilies and IFN-beta genes.

这些转录因子IRF3和IRF7的磷酸化作用导致其构象变化，从而允许其形成同源或异源二聚体。三种不同的二聚体组合（IRF3:IRF3、IRF7:IRF7以及IRF3:IRF7）可能分别选择性影响IFN-α基因亚家族和IFN-β基因的转录。