The cGAS-STING pathway drives type I IFN immunopathology in COVID-19

we profiled the inflammatory transcriptome of ten COVID-19 skin manifestations from patients with moderate-to-severe disease and compared the resultant signatures with those obtained from skin lesions of patients with cutaneous lupus erythematosus. Inflammation-oriented transcriptomics was performed on RNA extracted from skin biopsies using NanoString technologies