The impact of human salivary amylase gene copy number and starch on an in vitro model of oral biofilm formation

Periodontal disease progression is hypothesized to involve gene-environment interactions. Here, we evaluated a gene that may be a risk factor for periodontal disease, the copy number (CN) variant AMY1, by using an in vitro model of oral biofilm formation in which we cultured biofilms from human saliva samples with a range of AMY1 CNs and gum disease states.