Supplementary file 3_A Silent Epidemic of Congenital Anomalies and Its Predictors Among Newborns in Ethiopia: A Systematic Review and Meta-Analysis.docx

ObjectiveThis review was conducted with the aim of assessing the pooled prevalence of congenital anomalies and its predictors among newborns in Ethiopia.
MethodsThe relevant studies were identified by electronic database searching methods. All statistical analyses were carried out with STATA™ Version-14 software.
ResultsA total of 22 studies were included in this review. The pooled prevalence of congenital anomalies was 21.25 per 1,000 newborns. Age of the mother 35 years and above (POR = 3.29, 95% CI: 1.59–6.82) absence of formal education among mothers (POR = 1.35, 95% CI:1.12–1.63), maternal cigarate smoking (POR = 2.98, 95% CI:1.56–5.67), alcoholic drinking (POR = 2.66, 95% CI:1.28–5.51), chat chewing (POR = 3.37, 95% CI:1.57–7.21), no folic acid supplementation (POR = 4.29, 95% CI:2.35–7.83), pesticide exposure (POR = 3.23, 95% CI: 2.02–5.16), medication use during pregnancy (POR = 4.37, 95% CI:2.11–9.06), maternal chronic illness (POR = 3.76, 95% CI:1.72–8.20), preterm (POR = 2.35, 95% CI: 1.59–3.47), multiple pregnancy (POR = 3.66, 95% CI:1.99–6.71), low birth weight (POR = 5.46, 95% CI: 4.41–6.75) were identified as the predictors of congenital anomalies among newborns in Ethiopia.
ConclusionRelatively high burden of congenital anomalies were detected. Hence, strategies to minimize substance use, exposure to pesticide and medication, and to improve folic acid supplementation during pregnancy should be encouraged.