Supporting data for "The eradication of deep-seated infections induced by antibiotic-resistant bacteria using purposely designed stimulus-responsive biomaterials"

The rapid emergence and dissemination of drug-resistant bacteria undoubtedly poses a serious challenge to global public health. Developing new antibiotics has proved to be a feasible approach to coping with such drug-resistant bacteria; however, the development of new antibiotics consistently lags behind the emergence of new drug-resistant bacteria. Moreover, antibiotics treatments for deep-seated infections often fail because antibiotics are unable to reach the infection sites precisely. Hence, in this study, advanced exogenous technology (i.e., light, ultrasound, and microwave) stimuli-responsive biomaterials were fabricated to overcome drug-resistant bacteria in deep tissues. Under exogenous stimulation, the stimuli-responsive biomaterials rapidly produced bactericidal reactive oxygen species (ROS) and/or heat through electron transfer and a series of REDOX reactions. 

Meanwhile, the data include the characterization of stimulus-responsive biomaterials ( i.e., SEM, TEM, XRD, and so on), photothermal tests, photodynamic tests, sonodynamic tests, microwave thermal tests, in vitro antibacterial tests, in vitro cell regulation, in vivo antibacterial tests, in vivo bone regeneration, in vivo immunofluorescence technique, and so on. Details could be found in the dataset.

药物耐药细菌的迅速出现和传播无疑对全球公共卫生构成了严峻挑战。开发新型抗生素已被证明是应对此类耐药细菌的可行途径；然而，新型抗生素的开发始终滞后于耐药细菌的出现。此外，由于抗生素难以精确到达感染部位，针对深部感染的抗生素治疗往往失败。因此，在本研究中，我们制备了具有外部刺激响应特性的先进外源技术生物材料（即光、超声波和微波），以克服深部组织中的耐药细菌。在外部刺激下，这些刺激响应生物材料通过电子转移和一系列氧化还原反应迅速产生杀菌性活性氧（ROS）和/或热量。同时，数据集包括对刺激响应生物材料的表征（例如，扫描电子显微镜（SEM）、透射电子显微镜（TEM）、X射线衍射（XRD）等）、光热测试、光动力测试、声动力测试、微波热测试、体外抗菌测试、体外细胞调控、体内抗菌测试、体内骨再生、体内免疫荧光技术等内容。详细信息可参见数据集。